TCHPC is involved with a number of research projects in computational science, including:

• e-INIS
• QDFUN
• HPC-Europa
• STEREO with TCD Astrophysics
• The MMI Prostate Cancer Research Consortium
• The Irish African Partnership
• The Irish Longtitudinal Study on Aging
• SimSci (PRTLI5)
• Digital Repository of Ireland (PRTLI5)