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Trinity College Dublin

An investigation into the volumetric changes in the brains of APP/PS1 transgenic Alzheimer's mice.

Research Field: 
Life Sciences
Resource Type: 
Storage
Resource Type: 
Compute
Resource Class: 
C
Lead PI: 
Prof. Marina Lynch
Abstract: 
Alzheimer\'s disease (AD) is an incurable form of dementia, affecting more than 26 million people worldwide. The APP/PS1 line of double transgenic mice is a mouse model of AD, that has been shown to correlate with the behavioural and cognitive deficits associated with the human form of the disease. In this study, high resolution magnetic resonance imaging (MRI) was carried out on mice expressing both transgenes, and their wildtype littermates, to assess for any volumetric differences in the brains of the transgenic mice. These differences can then be correlate with neurobiological changes, including cell stress and neuronal atrophy.
Start Date: 
05/2011
Duration: 
12.00months

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