Investigating the effects of psychosis risk gene variants on functional and effective connectivity
Research Field:Life Sciences
Lead PI:Dr. Gary Donohoe
Abstract:Cognitive deficits associated with schizophrenia are not thought to be localised to a single part of the brain, but rather to represent more widespread cognitive dysfunction. As such, the study of this disorder may benefit from research focussing on the interactions between different brain regions. The proposed project will examine the effects of psychosis risk gene variants on functional and effective connectivity between neuronal populations. Functional neuroimaging will be conducted and samples for genotyping will be acquired from an Irish sample of schizophrenia patients and healthy controls. It is hoped that this research will help elucidate the mechanisms by which certain genes confer increased risk for schizophrenia. A clearer understanding of these mechanisms will help in the development of novel therapies for the disorder.