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Trinity College Dublin

Post-genomic investigation of coeliac disease susceptibility genes

Research Field: 
Life Sciences
Resource Type: 
Storage
Resource Type: 
Compute
Resource Class: 
C
Lead PI: 
Dr. Ross McManus
Abstract: 
Recently several new regions of the genome have been linked to the causation of coeliac disease. This study aims to investigate these associations with the aim of highlighting the genes or genetic variants which cause the association. We intend to use state of the art DNA sequencing technology to investigate gene expression in tissues of coeliac patients at a level of detail which was previously not possible. We will particularly concentrate on examining gene expression in T cells, from the peripheral blood and also from the intestines of affected individuals. We will also examine the function of transcription factors in these individuals and sequence genomic DNA. We will examine the function of some of the lesser well described genes by knocking down and increasing their expression in T cells using models of T cell function such as, migration and cytokine expression.
Start Date: 
04/2011
Duration: 
12.00months

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