Skip to main content »

Trinity College Dublin

Hippocampal volumetrics in an animal model of depression

Research Field: 
Life Sciences
Resource Type: 
Storage
Resource Type: 
Compute
Resource Class: 
C
Lead PI: 
Dr. Andrew Harkin
Abstract: 
High resolution anatomical images will be acquired for the determination of hippocampal volume in an animal model of depression. At the end of the experiment, perfused and post fixed brains will be cut into sections, processed and analysed for dendritic branch number according to a modified version of the rapid Golgi method. Neurobiological changes will be characterised by a reduction in hippocampal volume accompanied by neuronal atrophy and reduced dendritic aborisation. The ability of antidepressants to block these neuropathological changes will be determined.
Start Date: 
04/2011
Duration: 
12.00months

Last updated 08 Apr 2011Contact TCHPC: info | support.