The Web based platform for Optimization Parameters Regulatory Predictions in Drosophila
Research Field:Life Sciences
Lead PI:Dr. Juan Pablo Labrador
Abstract:Transcriptional factors (TFs) are proteins that bind in a specific DNA sequence. Their DNA binding domains recognize collections of short related DNA 'motifs’.Identification of regulatory binding motifs in DNA is a notoriously difficult task as these binding motifs are hidden amongst a vast amount of genomic noise. A wide range of computational methods to find cis regulatory sites has been proposed. However, at present individual computational techniques for the detection of binding sites have limited predictive value. The aim of this project is to develop and implement a web based platform with a collection of tools that work together to enhance the prediction of cis regulatory sites. The TCHPC clusters will be used to carry out comprehensive test runs of these tools to determine optimal parameter settings.