Subtle brain volumetric changes in patients with TLE
Research Field:Life Sciences
Resource Type:Dedicated human Support
Lead PI:Dr. Andrew Fagan
Abstract:70-80% patients with intractable temporal lobe epilepsy (TLE) have structural abnormalities in mesial temporal lobe, ammons horn of hippocampus, entorhinal cortex in the peri hippocampal area. Furthermore, studies have shown cortical involvement outside these areas in TLE patients. The affected areas show neuronal loss, lipofuscion accumulation in neurons, glial satellosis and fibrillary gliosis. Various studies have shown presence of volume loss in mesial temporal lobe and amygdala. When there is more than 50% neuronal loss in hippocampal area (with neuropeptide Y and somatostatin reorganization), the lesion can be called as mesial temporal sclerosis. The aim of the current study was to investigate whether significant volumetric differences could be measured in the brain of TLE patients compared to age- and gender-matched controls.
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